Peptidylglycine alpha amidating

The gene lists provided in this review are an update and extension of the first analysis of neurobiology-related gene families in The completeness of the analysis of individual gene families was assessed by a combination of domain searches using SMART, Inter Pro and Panther databases (Schultz et al., 2000; Zdobnov and Apweiler, 2001; Thomas et al., 2003; Mc Dowall and Hunter, 2011), by analysis gene families as shown in Tree Fam (Li et al., 2006) and, if necessary, by re-iterative BLASTP searches.It cannot be excluded that a more sophisticated sequence analyses may reveal additional family members.

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For example, a comprehensive understanding of the regulation of the often complex expression patterns of these genes in the nervous system will eventually explain how nervous systems are built.

Neurons are information processing devices that receive, integrate and transmit signals to induce specific patterns of behavior.

They can serve as quick reference guides for individual gene families or they can be used to mine large datasets (e.g., expression datasets) for genes with likely functions in the nervous system.

They also serve as a starting point for future projects.

All of these ion channel families are found in worms; however, voltage-gated sodium channels and P2X channels are not encoded in the genome.

The numbers next to the brackets indicate the number of subunits in multimeric channel structures.

This is because databases are populated by a large number of duplicate entries that either reflect differentially spliced isoforms arising from the same locus or trivial problems in duplicate gene naming.

In contrast to these databases, the counts presented in this review rely almost entirely on manual curation of gene families, with the exception of the chemosensory-subfamily of 7TMR genes with ~1,280 members, for which I relied, in large part, on the analysis by Robertson and Thomas described in The putative chemoreceptor families of .

Differences in the identity and function of individual neuron types can presumably be ascribed to the differential expression of specific members of these gene families.

Not the exact sum of individual numbers because some genes occur multiple times in different categories (auxiliary ion channel subunits—4 duplicates; ciliary components—7 duplicates; Ig/LRR—6 duplicates) Structural and regulatory genes involved in cytoskeletal organization (e.g., small GTPases) or in basic cellular processes are not considered here since most of them have broad functions in many different cell types and are also sometimes only transiently expressed in the nervous system.

One pervasive theme revealed by the analysis of many gene families is the nematode-specific expansions of many neuron function-related gene families, including, for example, many types of ion channel families, sensory receptors and neurotransmitter receptors.

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