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While more than 70 species of tobacco are known, the chief commercial crop is N. Tobacco use is a risk factor for many diseases, especially those affecting the heart, liver, and lungs, as well as many cancers.In 2008, the World Health Organization named tobacco as the world's single greatest preventable cause of death.The English word "tobacco" originates from the Spanish and Portuguese word "tabaco".

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In Taino, it was said to mean either a roll of tobacco leaves (according to Bartolomé de las Casas, 1552) or to tabago, a kind of Y-shaped pipe used for sniffing tobacco smoke (according to Oviedo; with the leaves themselves being referred to as cohiba).

Many Native American tribes have traditionally grown and used tobacco.

Following the scientific revelations of the mid-20th century, tobacco became condemned as a health hazard, and eventually became encompassed as a cause for cancer, as well as other respiratory and circulatory diseases.

In the United States, this led to the Tobacco Master Settlement Agreement, which settled the lawsuit in exchange for a combination of yearly payments to the states and voluntary restrictions on advertising and marketing of tobacco products.

Most nightshades contain varying amounts of nicotine, a powerful neurotoxin to insects.

However, tobaccos tend to contain a much higher concentration of nicotine than the others.

Many species of tobacco are in the genus of herbs Nicotiana.

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